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CasNo： 37115-32-5
MF： C19H18ClN5
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Adinazolam (ADZ) is a benzodiazepine-type new psychoactive substance (NPS) with anxiolytic, anticonvulsant, and antidepressant effects. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant properties.
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Description |
Adinazolam is a tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant properties. |
| Use |
Adinazolam is a benzodiazepine derivative used as an anxiolytic and antidepressant for treating anxiety disorders and clinical depression. |
The CAS number of ADINAZOLAM is 37115-32-5.
More information of ADINAZOLAM 37115-32-5 are:
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Synonyms |
1-(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)-N,N-dimethylmethanamine;Adinazolamum;ADINAZOLAM;C19H18ClN5;Deracyn; |
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CAS Number |
37115-32-5 |
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Molecular Formula |
C19H18ClN5 |
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Molecular Weight |
351.838 |
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Density |
1.31g/cm3 |
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Melting Point |
171-172.5° (US 4250094); mp 165-166° (DE 2201210) |
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Boiling Point |
527°Cat760mmHg |
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Flash Point |
272.5°C |
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PSA |
46.31000 |
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LogP |
2.76890 |
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Pka |
pKa 6.2 (D2O/DClor D2O/NaOD ) (Uncertain);5.8±0.1(D2O/DClor D2O/NaOD ) (Uncertain) |
Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex.
InChI:InChI=1/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3
Articles related to ADINAZOLAM:
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Article |
Source |
| Adinazolam, a Benzodiazepine-Type New Psychoactive Substance, Has Abuse Potential and Induces Withdrawal Symptoms in Rodents |
Su-Bin Hwang 1, Jae-Gyeong Lee 1, Youyoung Lee 1, Wun-A Kook 1, Seon-Kyung Kim 1, Audrey Lynn Donio 1, Hee-Won Min 1, Young-Jung Kim 1, Seok-Yong Lee 1, Choon-Gon Jang 1 , ACS Chem Neurosci . 2023 Sep 20;14(18):3487-3498. The intravenous self-administration (IVSA) test revealed that ADZ (0.01, 0.03, and 0.1 mg/kg/infusion) was self-administered significantly above vehicle levels, suggesting the reinforcing effect of ADZ. Furthermore, we revealed that treatment discontinuation following chronic ADZ administration (3 and 6 mg/kg) caused several somatic withdrawal symptoms in mice, including body tremor. |
| Fatal intoxication with U-47700 in combination with other NPS (N-ethylhexedrone, adinazolam, 4-CIC, 4-CMC) confirmed by identification and quantification in autopsy specimens and evidences |
Karolina Nowak, Paweł Szpot & Marcin Zawadzki , Forensic Toxicology, Volume 39, pages 493–505, (2021) The described case of fatal intoxication with NPS presented postmortem concentrations of U-47700, 4-CMC, N-ethylhexedrone, adinazolam and 4-CIC for the first time in the literature. The paper also showed stability study of these substances stored at + 4 °C for 775 days. |
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